Présentation
Gaël Ménasché received her Ph.D. from the University Pierre et Marie Curie, Paris (France) under the direction of Dr. Geneviève de Saint Basile at the Necker-Enfants malades hospital in 2004. Then, she performed her postdoctoral training in the Gary Koretzky’s lab in Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia (USA). In 2007, she joined INSERM at Imagine institute in Paris. Gaël Ménasché’s research has been focusing on molecular mechanisms underlying genetic immune disorders affecting immune homeostasis and the molecular dissection of the cytotoxic activity in lymphocytes through the study of primary hemophagocytic syndromes. This work has led to the identification of several key molecules regulating the trafficking and the docking steps of lytic granules. Based on this expertise, Gael Ménasché has progressively focused her research on regulated secretion processes and vesicular trafficking in immune cells and the genetic bases of severe allergic disorders.
Ressources & publications
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Journal (source)Proc. Natl. Acad. Sci. U.S.A.
Homozygous NLRP1 gain-of-function mutation in siblings with a syndromic form ...
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Journal (source)Nat. Med.
Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 a...
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Journal (source)Front Genet
Identification of an Endoglin Variant Associated With HCV-Related Liver Fibro...
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Journal (source)Proc. Natl. Acad. Sci. U.S.A.
Homozygous NLRP1 gain-of-function mutation in siblings with a syndromic form ...
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Journal (source)PLoS ONE
Prevalence and risk factors for latent tuberculosis infection among healthcar...
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Journal (source)Proc. Natl. Acad. Sci. U.S.A.
Pleiotropic effects for Parkin and LRRK2 in leprosy type-1 reactions and Park...
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Journal (source)J. Exp. Med.
Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reacti...
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Journal (source)J. Exp. Med.
Inherited IL-18BP deficiency in human fulminant viral hepatitis.
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Journal (source)Proc. Natl. Acad. Sci. U.S.A.
Homozygosity for TYK2 P1104A underlies tuberculosis in about 1% of patients i...
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Journal (source)Nucleic Acids Res.
SeqTailor: a user-friendly webserver for the extraction of DNA or protein seq...
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Journal (source)Proc. Natl. Acad. Sci. U.S.A.
Blacklisting variants common in private cohorts but not in public databases o...
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Journal (source)Sci Immunol
Tuberculosis and impaired IL-23-dependent IFN-γ immunity in humans homozygous...
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Journal (source)Bioinformatics
PopViz: a webserver for visualizing minor allele frequencies and damage predi...
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Journal (source)Hum. Mol. Genet.
A purely quantitative form of partial recessive IFN-γR2 deficiency caused by ...
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Journal (source)Front Immunol
CDG: An Online Server for Detecting Biologically Closest Disease-Causing Gene...
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Journal (source)Sci Rep
An eQTL variant of ZXDC is associated with IFN-γ production following Mycobac...
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Journal (source)Hepatology
A new 3p25 locus is associated with liver fibrosis progression in human immun...
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Journal (source)Oncotarget
BRIP1 coding variants are associated with a high risk of hepatocellular carci...
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Journal (source)J. Infect. Dis.
Major Loci on Chromosomes 8q and 3q Control Interferon γ Production Triggered...
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Journal (source)PLoS ONE
Impact of IL28B, APOH and ITPA Polymorphisms on Efficacy and Safety of TVR- o...
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Journal (source)Sci Rep
An eQTL variant of ZXDC is associated with IFN-γ production following Mycobac...
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Journal (source)Lancet Infect Dis
Genetics of human susceptibility to active and latent tuberculosis: present k...
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Journal (source)Semin. Immunol.
Human genetics of infectious diseases: Unique insights into immunological red...
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Journal (source)Nat. Rev. Immunol.
A novel genetic architecture of infectious diseases.
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Journal (source)Proc. Natl. Acad. Sci. U.S.A.
Common homozygosity for predicted loss-of-function variants reveals both redu...
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Journal (source)Science
Auto-antibodies against type I IFNs in patients with life-threatening COVID-19.
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Journal (source)Science
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.
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Journal (source)J Exp Med
Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever...
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Journal (source)Sci Immunol
Polyclonal expansion of TCR Vbeta 21.3+ CD4+ and CD8+ T cells is a hallmark o...
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Journal (source)Sci Immunol
Polyclonal expansion of TCR Vbeta 21.3+ CD4+ and CD8+ T cells is a hallmark o...
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Journal (source)Sci Immunol
Polyclonal expansion of TCR Vbeta 21.3+ CD4+ and CD8+ T cells is a hallmark o...
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Journal (source)Nat Med
Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child.
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Journal (source)Nature
Human genetic and immunological determinants of critical COVID-19 pneumonia.
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Journal (source)J Exp Med
Incontinentia pigmenti underlies thymic dysplasia, autoantibodies to type I I...
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Journal (source)J Exp Med
Gain-of-function human UNC93B1 variants cause systemic lupus erythematosus an...